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I have been using my portable hard disk drive for more than an year now. Its a laptop hard-disk of 2.5 inches, 80GB capacity with a USB 2.0 casing. By now the drive has become nearly full, there is little free space.
Three days back, I got a warning saying
“Windows delayed write failed - Windows was unable to save all the data for the file M:\$Mft. The data has been lost. This error may be caused by a failure of your computer hardware or network connection. Please try to save this data elsewhere.”
For a moment I thought that disk is going faulty, but with some hit and trial, I got it fixed.
Let me share the solution with you.
Fix:
This kind of problem is observed when the drive is almost full and there is some problem being faced by the disk in maintaining the file allocation table. This problem can be fixed in some easy steps:
2. Open My Computer, right click on the USB drive, click on properties.
3. Go to Tools > Error-checking and select option to check now as shown in the image below.
4. This will show a window like the one below. Check the check-boxes to Automatically fix the file system and Scan for and attempt recovery of bad sectors. Click Start.
Majority of the virus problem which we receive from the readers are those cases which infect the system through pen drives. According to our records about 40 percent of the total computer systems got virus or trojan infection through pen drives and USB portable devices like iPOd, Mp3 players etc.
Yesterday, I found a cool utility called Thumbscrew : USB Write Blocker , you can use this utility to disable writing to your USB drive. You can read full review about the utility here

Let’s see how can you use this utility to protect your drive from viruses
Fix:
Thumbscrew is small handy utility which you can take any where on your pen drive use it to protect your pen drive from viruses on other computer systems by disabling Writing on that system. You can download thumbscrew here.
Follow the procedure below to protect your pen drive from viruses
1. In order to protect your pen drive from viruses you need to create a blank file named autorun.inf through notepad and place it in the root directory.
2. When you insert pen drive on any virus infected computer system it will throw a message that some thing is trying to copy and replace a file located in the root directory of your USB device and that is nothing but a virus.
Source :
http://www.troublefixers.com/disable-data-writing-on-your-usb-drive-to-protect-it-from-viruses/